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The Brain Wash Book by Dr. David Perlmutter &Dr. Austin Perlmutter

Updated: Sep 11, 2021

What happens in the brain when we are exposed to stress?

  1. Stress pathways are activated by amygdala;


  1. preforantal cortex regulation is impaired ;

  2. amygdala function is strengthened


Why do we become impulsive and irrational when we are stressed?


The way our brains response to stresssful events changes from slow and thoughtful prefrontal cortex control to the reflexive and rapid emotional responses(being impulsive and irrational)of the amygdala and related limbic structures.


How does the chronic inflammation making us lose grips on ourselves?


A recent case study on patients suffering from depression was conducted by the Emory University. It was found that inflammation is associated with weakened connections between the amygdala and the prefrontal cortex.


Large datasets reveal that high-glycemic-index foods can contribute to depression which is done through inflammation pathways. Poor choices in food, sleep deprivation, an inactive lifestyle and lack of exposure to nature are few reasons why inflammation is amped up in our bodies.


It is vital to understand that anything that intensify inflammation may threaten our ability to use our prefrontal cortices, leaving the amygdala to its own devices. This means that the prefrontal cortex becomes unable to help dialing down our impulsive behaviour and we become having less control over our actions and emotions.


Does chronic stress have a physical effect on the brain?

Yes, chronic stress alters the physical structure of the prefrontal cortex and it also promotes new neuron growth in the amygdala.


Why does the brain crave sugar?

Our desire for sugar is hardwired in the brain because sugar helped our ancestors to produce and store body fat, providing an energy resorvoir during the caloric scarcity of winter, creating a survival advantage.


Sugar intake directly activates the brain’s dopamine reward pathway and the more this pathway is rewarded, the more it needs to be stimulated. Over stimulation of the reward system alters dopamine signalling which weakens the prefrontal cortex. This leads the brain to be less able to control impulsive urges and addictive tendencies or behaviour. In other words, sugar hacks into your reward pathway system and alter your neurochemistry to keep you coming back for more.



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